Contents

KCNK17 Protein

🔬 Protein Info

Gene Symbol	KCNK17
Aliases	KCNK17PROTEIN
Function	KCNK17 (Potassium Two Pore Domain Channel Subfamily K Member 17), also known as TASK-4 or TALK-2, is a member of the two-pore domain (K2P) potassium channel family.
Subcellular Localization	</strong></td><td>Cell membrane</td></tr> [@hille2001]
Molecular Weight	40 kDa
GeneCards	KCNK17
Human Protein Atlas	KCNK17
N-terminus	Intracellular domain involved in channel trafficking and regulation
Transmembrane segments	Four alpha-helices (M1-M4) that span the membrane
Pore domains	Two highly conserved selectivity filter regions (P1 and P2) that confer K+ selectivity
C-terminus	Intracellular domain containing regulatory motifs and interaction sites
Lung	High expression in pulmonary tissue, particularly alveolar epithelial cells
Kidney	Present in renal tubules, contributing to renal function
Pancreas	Expressed in pancreatic beta-cells, potentially affecting insulin secretion
Brain	Detected in various brain regions including the hippocampus and cortex
Databases	GeneCards UniProt NCBI Gene HPA STRING

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