| Gene Symbol | Lysine Demethylase 2A |
| Chromosome | 11q13.1 |
| Protein Type | Fe(II)/2-oxoglutarate-dependent dioxygenase |
| Function | is a histone demethylase that specifically removes methyl groups from histone H3 at lysine 36 (H3K36). |
| Primary Expression | Ubiquitous, highest in brain and testis |
| Subcellular Localization | </strong> Nucleus</div> |
| Molecular Weight | 130 kDa |
| UniProt ID | Q9Y2K2 |
| NCBI Gene ID | 22992 |
| Ensembl ID | ENSG00000107140 |
| OMIM | 605469 |
| JmjC Domain | The catalytic domain that requires Fe²⁺ and 2-oxoglutarate as cofactors for demethylase activity |
| F-box Domain | Involved in protein-protein interactions and substrate recognition |
| LRR Domain | Leucine-rich repeat region for additional protein interactions |
| CXXC Domain | Zinc finger motif that binds to unmethylated CpG DNA sequences |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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