protein 1,345 words KG: KINESIN1 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

Kinesin-1 Heavy Chain Protein

🔬 Protein Info
Gene SymbolKINESIN1
Functionis a microtubule-based motor protein that transports cargo along axonal and dendritic pathways.
Amino Acids963 aa
GeneCardsKINESIN1
Human Protein AtlasKINESIN1
Motor domain (head)Located at the N-terminus, contains microtubule binding site and ATPase activity
Coiled-coil stalkMediates dimerization and cargo binding
Tail domainBinds to cargo adaptors and regulates motor activity
Light chain subunitAssociates with heavy chain for cargo recognition
Synaptic componentsTransports synaptic vesicles, vesicle precursors, and neurotransmitter receptors
Mitochondrial traffickingMediates distribution of mitochondria along axons [@diefenbacher2020]
Protein complexesCarries signaling molecules, kinases, and transcription factors
Membrane organellesMoves endosomes, Golgi-derived vesicles, and lysosomes
SynaptogenesisDelivers synaptic proteins to developing synapses
Synaptic plasticityMaintains synaptic vesicle pools and receptor distribution
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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