| Gene Symbol | KINESIN3 |
| Aliases | KINESIN3PROTEIN |
| Function | KIF1A (Kinesin-3 Family Member) is a monomeric motor protein that transports synaptic vesicle precursors, dense-core vesicles, mitochondria, and other cargoes along axonal microtubules[@vale1995]. |
| Subcellular Localization | </strong></td><td>Axons</td></tr> |
| GeneCards | KINESIN3 |
| Human Protein Atlas | KINESIN3 |
| Motor domain (aa 1-350) | Contains the microtubule-binding site and ATPase activity that drives movement |
| Coiled-coil domain (aa 350-650) | Mediates dimerization (although KIF1A functions as a monomer, the CC domain can form dimers under certain conditions) |
| PHA domain (aa 650-800) | Phosphorylation-regulated cargo-binding domain |
| C-terminal tail (aa 800-1750) | Variable region that determines cargo specificity |
| Synaptic vesicle precursors | Transport of synaptophysin, synaptotagmin, and VAMP2 to presynaptic terminals |
| Dense-core vesicles | Transport of neurotrophins and neuropeptides |
| Mitochondria | Distribution of mitochondria to distal axons |
| RNA granules | Transport of mRNAs for local translation |
| Synaptic proteins | BDNF, TrkB, and other essential synaptic components |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |