| Gene Symbol | KYAT3 |
| Aliases | KYAT3PROTEIN |
| Protein Type | Enzyme |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | multiple tissues: |
| Subcellular Localization | </td><td>Cytoplasm, Mitochondria</td></tr> |
| Molecular Weight | 45 kDa |
| Ensembl ID | ENSG00000135926 |
| GeneCards | KYAT3 |
| Human Protein Atlas | KYAT3 |
| PLP-binding Domain | Pyridoxal phosphate cofactor for transamination |
| Dimerization Interface | Forms functional homodimers |
| Active Site Pocket | Substrate-specific binding for kynurenine and cysteine conjugates |
| KYNA Deficiency | Reduced KYAT3 leads to lower KYNA, increasing excitotoxicity |
| Seizure-Induced Changes | Acute seizures alter KYAT3 expression |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!