| Gene Symbol | MADD |
| Aliases | MAP3K14 Associated Death Domain Protein |
| Function | MADD is highly expressed in the central nervous system, particularly in hippocampal neurons, cortical pyramidal cells, and dopaminergic neurons of the substantia nigra. |
| Subcellular Localization | </span><span class="infobox-value">Cytoplasm, Golgi apparatus, Mitochondria</span></div> |
| Molecular Weight | 95 kDa |
| Amino Acids | 836 aa |
| Pathways | NF-κB signaling |
| GeneCards | MADD |
| Human Protein Atlas | MADD |
| Death Domain | The C-terminal death domain shares structural homology with other death domain proteins (FADD, TRADD) and mediates interactions with TNF receptor superfamily members |
| Multiple Phosphorylation Sites | MADD is phosphorylated at several residues (Ser71, Thr233, Ser389), regulating its pro-survival versus pro-apoptotic functions |
| TNF Receptor Signaling | MADD binds to TNF receptor 1 (TNFR1), Fas receptor (CD95), and DR6, mediating both survival and death signals depending on cellular context |
| Caspase Activation | MADD can recruit and activate caspase-8 and caspase-9, initiating the extrinsic and intrinsic apoptotic pathways |
| Survival Signaling | Under certain conditions, MADD also activates NF-κB and MAPK pathways that promote cell survival |
| NF-κB Activation | MADD interacts with TRAF proteins to activate the NF-κB pathway, promoting expression of anti-apoptotic genes including Bcl-2, c-FLIP, and XIAP |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |