| Gene Symbol | MAN2B1 |
| Full Name | Mannosidase Alpha Class 2B Member 1 |
| Chromosome | 19q13.13 |
| Function | The MAN2B1 gene encodes acid alpha-mannosidase, a lysosomal hydrolase that catalyzes the hydrolysis of terminal alpha-mannose residues from mannose-containing oligosaccharides. |
| Primary Expression | most tissues, with highest levels in: |
| Molecular Weight | 280 kDa |
| UniProt ID | O00754 |
| NCBI Gene ID | 4125 |
| Ensembl ID | ENSG00000112837 |
| OMIM | 604458 |
| GeneCards | MAN2B1 |
| Human Protein Atlas | MAN2B1 |
| Precursor Form | 1,001 amino acid precursor |
| Proteolytic Processing | Cleaved into heavy chain (~70 kDa) and light chain (~30 kDa) |
| N-glycosylation | Multiple N-linked glycosylation sites essential for proper folding and lysosomal targeting |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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