| Gene Symbol | MAP3K12 |
| Full Name | Mitogen-Activated Protein Kinase Kinase Kinase 12 |
| Aliases | MAP3K12PROTEIN |
| Protein Type | Kinase |
| Function | MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12), also known as DLK (Dual-Leucine Zipper Kinase), is a serine/threonine protein kinase that functions as a key regulator of stress-activated |
| Primary Expression | neurons throughout the CNS
- Regional Distribution: High expression in hippocampus, cortex |
| Pathways | MAPK pathway |
| GeneCards | MAP3K12 |
| Human Protein Atlas | MAP3K12 |
| MKK4/MKK7 | Phosphorylation |
| JNK3 | Downstream activation |
| c-Jun | Transcription factor |
| TDP-43 | Stress response |
| Sarm1 | Parallel pathway |
| Associated Diseases | neurodegeneration |
| Interactions | DRP1 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |