| Gene Symbol | MGLUR2 |
| Aliases | mGluR2/GRM2 |
| Chromosome | 7q31.1 |
| Protein Type | Receptor |
| Function | mGluR2 is a Group II metabotropic glutamate receptor coupled to Gi/o proteins. |
| Molecular Weight | 96 kDa |
| Exons | 10 |
| Pathways | NF-κB |
| GeneCards | MGLUR2 |
| Human Protein Atlas | MGLUR2 |
| N-terminal Venus Fly Trap (VFT) domain | Large extracellular domain (∼400 aa) containing the glutamate binding site |
| Cysteine-rich domain (CRD) | Linker between VFT and 7TM domain, contains disulfide bonds |
| 7 Transmembrane domain | Classic GPCR structure (TM1-TM7) |
| C-terminal intracellular tail | Contains serine/threonine residues for phosphorylation and PDZ interaction motifs |
| Region | Expression Level |
| Associated Diseases | neurodegeneration |
| Interactions | AMYLOID, AMYLOID-BETA |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |