| Gene Symbol | MGLUR8 |
| Aliases | mGluR8/GRM8 |
| Chromosome | 7q31.3 |
| Protein Type | Receptor |
| Function | mGluR8 is a Group III metabotropic glutamate receptor functioning as a presynaptic autoreceptor in cortical and hippocampal regions. |
| Molecular Weight | 105 kDa |
| Exons | 9 |
| GeneCards | MGLUR8 |
| Human Protein Atlas | MGLUR8 |
| N-terminal VFT domain | Large extracellular domain (~400 aa) with high glutamate affinity |
| Cysteine-rich domain | Flexible linker with structural disulfide bonds |
| 7 Transmembrane domain | Classic seven-helix bundle |
| C-terminal tail | Intracellular domain with interaction motifs |
| Region | Expression Level |
| Olfactory bulb | Very high |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |