| Gene Symbol | MITOFUSIN2 |
| Aliases | MITOFUSIN2PROTEIN |
| Function | Mitofusin-2 (MFN2) is a dynamin-related GTPase embedded in the mitochondrial outer membrane that mediates mitochondrial fusion, endoplasmic reticulum-mitochondria tethering, and mitophagy. |
| GeneCards | MITOFUSIN2 |
| Human Protein Atlas | MITOFUSIN2 |
| N-terminal GTPase domain | Hydrolyzes GTP to power membrane fusion |
| HR1 (heptad repeat 1) | Mediates dimerization |
| Two transmembrane domains | Anchor protein in outer membrane (both N- and C-termini cytosolic) |
| HR2 (heptad repeat 2) | Forms antiparallel coiled-coils for tethering |
| Coiled-coil regions | Mediate protein-protein interactions |
| Homotypic interactions | MFN2-MFN2 complexes |
| Heterotypic interactions | MFN2-MFN1 complexes for fusion |
| R94Q | Impaired GTPase activity |
| T105M | Altered mitochondrial distribution |
| R364W | Disrupted fusion activity |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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