| Gene Symbol | NCADHERIN |
| Aliases | NCADHERINPROTEIN |
| Chromosome | 18q12.1 |
| Function | N-cadherin (Neural Cadherin, also known as Cadherin-2 or CDH2) is a calcium-dependent cell adhesion molecule critical for neuronal development, synaptic plasticity, and maintenance of neural circui... |
| GeneCards | NCADHERIN |
| Human Protein Atlas | NCADHERIN |
| Nervous system | Neurons, astrocytes, and Schwann cells |
| Development | High expression during embryogenesis |
| Adult brain | Maintained at synapses and in certain populations |
| Non-neural tissues | Expressed in mesenchymal cells, endothelial cells[@cdh2019] |
| Extracellular domain | Five cadherin repeats (EC1-EC5) for adhesion |
| Calcium binding sites | Ca²⁺ between repeats maintains rigidity |
| Transmembrane domain | Single-pass membrane-spanning helix |
| Cytoplasmic domain | Connects to actin cytoskeleton via catenins |
| C-terminal β-catenin binding site | Enables signaling functions[@ncadherin2018] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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