| Gene Symbol | NCASTRIN |
| Aliases | NCASTRINPROTEIN |
| Function | Nicastrin Protein Gamma Secretase Component is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and... |
| Subcellular Localization | </strong></td><td>Endoplasmic reticulum, Golgi apparatus, Plasma membrane</td></tr> |
| GeneCards | NCASTRIN |
| Human Protein Atlas | NCASTRIN |
| Large Ectodomain | ~90 kDa extracellular/luminal domain with multiple glycosylation sites |
| Single Transmembrane Helix | ~20 amino acid hydrophobic segment |
| Small Cytoplasmic Tail | ~30 amino acids with trafficking signals |
| Diverse Alpha-Propeller | The ectodomain adopts a diverse alpha-propeller structure important for substrate recognition |
| Glycosylation | Heavily N-glycosylated, which is important for folding and function |
| Conservation | Highly conserved across species |
| Substrate Recognition | Binds to the extracellular domain of gamma-secretase substrates |
| Complex Assembly | Essential for proper assembly of the gamma-secretase complex |
| Catalytic Activity | Required for gamma-secretase proteolytic activity |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |