| Gene Symbol | NCX |
| Aliases | NCXPROTEIN |
| Function | The sodium-calcium exchanger (NCX) is a plasma membrane antiporter that exchanges three Na⁺ ions for one Ca²⁺ ion. NCX can operate in both directions depending on the electrochemical gradients, but... |
| GeneCards | NCX |
| Human Protein Atlas | NCX |
| Nine transmembrane helices (TM1-9) | Form ion transport pathway |
| Two clusters | TM1-5 and TM6-9, separated by large intracellular loop |
| Two α-catalytic repeats (α1, α2) | Highly conserved, essential for transport |
| NCX1 (SLC8A1) | Ubiquitous, high in heart, brain (neurons + astrocytes) |
| NCX2 (SLC8A2) | Brain-specific, neurons |
| NCX3 (SLC8A3) | Brain, skeletal muscle, not heart[@philipson2000] |
| Cytoplasmic Na⁺ | Ionic regulation |
| Cytoplasmic Ca²⁺ | Activation |
| PIP2 | Relieves autoinhibition |
| Phosphorylation | PKC, PKA effects |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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