| Gene Symbol | NEUROFILAMENTHEAVYCHAIN |
| Aliases | NEUROFILAMENTHEAVYCHAIN |
| Subcellular Localization | </b></td><td>Axon, neuronal soma, dendrites</td></tr> |
| NF-L (Light) | 60 kDa |
| NF-M (Medium) | 95 kDa |
| NF-H (Heavy) | 200 kDa[@lee2024] |
| KSP repeats | Approximately 50-60 repeat units |
| Phosphorylation | Serine and threonine residues within these repeats are phosphorylated |
| Large axons | Contain high levels of phosphorylated NF-H |
| Small axons | Have minimal NF-H content |
| Axonal swellings | Occur when NF-H is misregulated |
| Kinesin motors | Drive anterograde transport (cell body to synapse) |
| Dynein motors | Drive retrograde transport (synapse to cell body) |
| phosphorylation state | Affects motor protein binding and transport rates |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!