protein 2,736 words KG: NEUROFILAMENTHEAVYCHAIN 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

Neurofilament Heavy Chain (NF-H)

🔬 Protein Info
Gene SymbolNF-H
AliasesNEUROFILAMENTHEAVYCHAIN
FunctionNeurofilaments are type IV intermediate filaments specifically expressed in neurons.
Subcellular Localization</b></td><td>Axon, neuronal soma, dendrites</td></tr>
GeneCardsNF-H
Human Protein AtlasNF-H
NF-L (Light)60 kDa
NF-M (Medium)95 kDa
NF-H (Heavy)200 kDa[@lee2024]
KSP repeatsApproximately 50-60 repeat units
PhosphorylationSerine and threonine residues within these repeats are phosphorylated
Large axonsContain high levels of phosphorylated NF-H
Small axonsHave minimal NF-H content
Axonal swellingsOccur when NF-H is misregulated
Kinesin motorsDrive anterograde transport (cell body to synapse)
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph