| Gene Symbol | NGB |
| Aliases | NGBPROTEIN |
| Function | Neuroglobin (NGB) is a neuronal-specific globin protein that provides neuroprotection against hypoxia, oxidative stress, and neurodegenerative diseases. |
| Subcellular Localization | in neurons, with lower expression in glial cells |
| Molecular Weight | 17 kDa |
| GeneCards | NGB |
| Human Protein Atlas | NGB |
| Heme pocket | Contains a heme b prosthetic group with iron center |
| Globin fold | Similar to myoglobin but with unique structural features |
| Dimerization interface | Can form homodimers under certain conditions |
| Tyr B10 and Gln E7 | Key residues affecting oxygen affinity |
| Amyloid toxicity | A-beta exposure reduces NGB expression |
| Oxidative stress | NGB protects against ROS accumulation |
| Mitochondrial protection | Preserves neuronal energy metabolism |
| Therapeutic potential | NGB overexpression improves cognitive function in AD models |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |