| Gene Symbol | NRP2PROTEIN |
| Protein Type | Receptor |
| Function | is a transmembrane co-receptor protein that plays essential roles in development and adult physiology by mediating interactions between cells and their microenvironment. |
| Subcellular Localization | ** | Plasma membrane, cytoplasm, endosomes | |
| Molecular Weight | 110 kDa |
| Amino Acids | 40 aa |
| GeneCards | NRP2PROTEIN |
| Human Protein Atlas | NRP2PROTEIN |
| Mammalian Notch Homology Domain (c) | This region mediates interactions with other receptors, particularly in the context of VEGF receptor co-receptor function. The c domain also plays a role in NRP2 self-association. |
| PDZ Domain Binding Motif | The C-terminal PDZ binding motif (SEA) allows NRP2 to interact with PDZ domain-containing scaffold proteins including NRP1-associated molecules, enabling formation of signaling complexes. |
| Serine/Threonine Residues | Potential phosphorylation sites regulate protein interactions and signaling. |
| Axon Collateral Formation | Beyond initial guidance, NRP2 signaling influences the formation of axon collaterals and synaptic connections. |
| Circuit Assembly | By precisely controlling axon targeting, NRP2 contributes to the establishment of functional neural circuits including those in the limbic system, visual cortex, and spinal cord. |
| VEGF-C/VEGF-D Signaling | NRP2 forms complexes with VEGF receptor 2 (VEGFR2) and enhances VEGF-C and VEGF-D signaling, promoting lymphatic endothelial cell proliferation and lymphatic vessel formation. |
| Angiogenesis | NRP2 also modulates blood vessel formation through interactions with VEGF-A and other VEGFs. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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