| Gene Symbol | NUP58PROTEIN |
| Protein Type | Channel |
| Function | is a crucial component of the nuclear pore complex (NPC) central channel. |
| Subcellular Localization | </strong></td><td>Nuclear envelope, Nuclear pore complex</td></tr> |
| Molecular Weight | 58 kDa |
| Amino Acids | 483 aa |
| GeneCards | NUP58PROTEIN |
| Human Protein Atlas | NUP58PROTEIN |
| N-terminal coiled-coil domain | Mediates dimerization with NUP54, forming the structural core of the central channel |
| Central FG repeat region | Contains phenylalanine-glycine (FG) repeat motifs that create the selective permeability barrier |
| C-terminal domain | Contributes to nuclear basket association and regulatory interactions |
| NUP58-NUP54 Heterodimer | Forms a stable coiled-coil dimer essential for central channel structure |
| FG Repeat Motifs | ~20 FG repeats create a meshwork that allows selective transport |
| Asymmetric Distribution | NUP58 is preferentially located on the nuclear side of the NPC |
| Phosphorylation Sites | Regulated by kinases including CDK1 during cell cycle |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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