| Gene Symbol | OPTOIN1PROTEIN |
| Aliases | OPTOIN1PROTEIN |
| Function | ### Autophagy Receptor Function |
| Subcellular Localization | </strong></td><td>Cytoplasm, Golgi, nucleus, mitochondria</td></tr> |
| Intermediate domain (aa 150-350) | Contains the LC3-interacting region (LIR) essential for autophagy function. |
| C-terminal domain (aa 450-577) | Contains additional protein interaction motifs. |
| LIR motif | LC3-interacting region (LIR, aa 236-259) binds LC3/GABARAP family proteins |
| UBA domain | Ubiquitin-associated domain binds ubiquitin chains |
| Zinc finger | C3HC4 RING finger motif (present in some isoforms) |
| Phosphorylation sites | Multiple serine/threonine phosphorylation sites regulate function (Acharya et al., 2019) |
| Phosphorylation | TBK1 phosphorylates OPTN, enhancing its autophagy receptor function |
| Ubiquitination | OPTN itself can be ubiquitinated, affecting its localization and function |
| Sumoylation | Some evidence for SUMO modification |
| Protein aggregates | OPTN binds ubiquitinated protein aggregates for autophagic clearance |
| Intracellular bacteria | OPTN participates in xenophagy (antibacterial autophagy) |
| Damaged organelles | Recognizes damaged mitochondria and other organelles |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |