| Gene Symbol | P38A |
| Protein Family | p38 MAPK family |
| Protein Type | Serine/Threonine Kinase |
| Function | p38α is a serine/threonine kinase activated by cellular stress, cytokines, and inflammatory stimuli. |
| Primary Expression | neurons and glia and contributes to neuroinflammation, amyloid-beta production, and [tau](/entities/tau |
| Molecular Weight | 41.3 kDa |
| UniProt ID | [Q16539](https://www.uniprot.org/uniprot/Q16539) |
| GeneCards | P38A |
| Human Protein Atlas | P38A |
| MAPK Pathway | ERK1/2, JNK, p38β, p38γ, p38δ |
| Upstream Kinases | MKK3, MKK6, TAB1, ASK1 |
| Transcription Factors | ATF2, CREB, p53 |
| Neurodegenerative Conditions | Alzheimer's disease, Parkinson's disease, ALS, Huntington's disease |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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