protein 623 words KG: P62SQSTM1PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

p62/SQSTM1 Protein

🔬 Protein Info
Gene SymbolP62SQSTM1
AliasesP62SQSTM1PROTEIN
Chromosome5q35.3
Protein FamilySelective autophagy receptors (SARs)
Protein TypeScaffold Protein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localizationnearly all major neurodegenerative diseases, including [alzheimers](/diseases/al
Molecular Weight~62 kDa
Amino Acids440
UniProt IDQ13501
GeneCardsP62SQSTM1
Human Protein AtlasP62SQSTM1
Associated Diseasesneurodegeneration
InteractionsNBR1, WAS, MYOT, P62, NEMO, CGAS
KG Connections40 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Autophagosome Maturation Checkpoint Control
Score: 0.49
Lysosomal Membrane Repair Enhancement
Score: 0.45
VCP-Mediated Autophagy Enhancement
Score: 0.41
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (9)

What determines the spatial organization of autophagy recept
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (4)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
iPSC-NPC transplantation in ICH animal model
validation · proposed · Score: 0.85
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in