| Gene Symbol | PDE1BPROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | brain regions associated with learning and memory |
| Subcellular Localization | PDE activity creates cAMP microdomains ### Calcium Signaling Integration PDE1B |
| Molecular Weight | 59 kDa |
| GeneCards | PDE1BPROTEIN |
| Human Protein Atlas | PDE1BPROTEIN |
| N-terminal regulatory domain | Contains two calcium/calmodulin-binding sites |
| Catalytic domain | Carboxy-terminal region with cAMP/cGMP hydrolysis activity |
| Calmodulin activation | Requires calcium-bound calmodulin for activation |
| Dimerization | Forms homodimers for proper function |
| cAMP levels | Controls intracellular cAMP concentration |
| cGMP levels | Also hydrolyzes cGMP, though preferentially cAMP |
| Spatial signaling | Localized PDE activity creates cAMP microdomains |
| Calcium influx | Activates PDE1B via calmodulin |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!