protein 792 words KG: PDHA2PROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PDHA2 Protein

🔬 Protein Info
Gene SymbolPDHA2
AliasesPDHA2PROTEIN
FunctionThe protein forms an α₂β₂ heterotetramer with PDHB (E1 beta subunit). PDHA2 has three serine phosphorylation sites that regulate activity: phosphorylation inactivates the enzyme, while dephosphoryl...
Subcellular Localization</strong> Mitochondrial matrix</div> <div class="infobox-row"><strong>Protei
Molecular Weight43 kDa
GeneCardsPDHA2
Human Protein AtlasPDHA2
N-terminal RegionContains the binding site for the lipoyl cofactor
C-terminal Catalytic DomainContains the thiamine pyrophosphate (TPP) binding site
Phosphorylation SitesS293, S300, and S232 (regulatory serine residues)
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph