| Gene Symbol | PFBN1 |
| Aliases | PFBN1PROTEIN |
| Subcellular Localization | </strong></td><td>Cytoplasm, cytoskeleton</td></tr> |
| Molecular Weight | 15 kDa |
| GeneCards | PFBN1 |
| Human Protein Atlas | PFBN1 |
| Seven β-strands | Form the protein core and create the binding interface |
| Two α-helices | N-terminal and C-terminal helices contribute to function |
| Poly-L-proline binding site | Recognizes proline-rich sequences in various proteins |
| Actin binding interface | Contacts G-actin to regulate polymerization |
| Dominant mutations | PFBN1 mutations cause familial ALS |
| Motor neuron degeneration | Loss of PFBN1 function leads to motor neuron death |
| Cytoskeletal disruption | Mutations disrupt actin dynamics essential for neuronal function |
| Stress granule dynamics | PFBN1 associates with stress granules under cellular stress |
| Synaptic function | PFBN1 regulates dendritic spine actin structure |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |