protein 803 words KG: PIK3C3VPS34 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PIK3C3 Protein

🔬 Protein Info
Gene SymbolPIK3C3
AliasesVPS34
Chromosome18q12.3
Protein FamilyClass III Phosphoinositide 3-kinase (PI3K3C)
Subcellular LocalizationCytosol, endosomal membrane, phagophore
Molecular Weight100 kDa
Amino Acids887 aa
Exons32
PathwaysPI3K
UniProt IDQ8N3F7
Ensembl IDENSG00000055070
GeneCardsPIK3C3
Human Protein AtlasPIK3C3
Associated DiseasesAD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsEGFR, PPARG, HSPA5, MAVS, FIP200, AMBRA1
KG Connections1124 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.46
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.46
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.46
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.46
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.46

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in