| Gene Symbol | PLXNA2 |
| Aliases | PLXNA2PROTEIN |
| Chromosome | 1q23.3 |
| Protein Type | Gene |
| Function | encodes a member of the plexin family of transmembrane receptors for semaphorins, playing critical roles in neural development, circuit formation, and synaptic plasticity. |
| Molecular Weight | 220 kDa |
| Amino Acids | 034 aa |
| Exons | 33 |
| GeneCards | PLXNA2 |
| Human Protein Atlas | PLXNA2 |
| Semaphorin-Binding Domains (SBD) | Multiple extracellular domains that directly bind semaphorin ligands with varying affinities |
| Cysteine-Rich Repeats (CR) | Flexor-free modules that participate in receptor dimerization and activation |
| Transmembrane Domain | Single pass helix connecting extracellular and intracellular domains |
| Cytoplasmic GAP Domain | Ras GTPase-activating protein domain that inactivates R-Ras family GTPases, mediating intracellular signaling cascades 2 |
| Cerebellar Circuits | Guides Purkinje cell dendrites and parallel fiber innervation |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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