Contents

PM20D1 Protein

🔬 Protein Info

Gene Symbol	PM20D1
Full Name	Peptidase M20 Domain Containing 1
Protein Family	M20 peptidase family
Function	is a mitochondrial peptidase that has emerged as a significant player in Parkinson's disease (PD) pathogenesis.
Subcellular Localization	Mitochondria, Cytoplasm
Molecular Weight	58 kDa
Amino Acids	400 aa
UniProt ID	Q9NWU1
GeneCards	PM20D1
Human Protein Atlas	PM20D1
Mitochondrial Targeting Sequence	An N-terminal targeting sequence directs PM20D1 to mitochondria. This sequence is cleaved upon mitochondrial import, yielding the mature protein.
Dimerization Interface	PM20D1 likely functions as a homodimer, with dimerization mediated by residues in the C-terminal region. Dimer formation may be required for enzymatic activity.
Protein Interaction Domains	Regions outside the catalytic domain likely mediate interactions with other proteins, including components of the mitochondrial protein quality control machinery.
Peptidase Activity	As a member of the M20 peptidase family, PM20D1 may hydrolyze peptide bonds. Substrates could include mitochondrial peptides generated during protein turnover or imported from the cytosol.
Amino Acid Metabolism	PM20D1 may participate in amino acid catabolism or synthesis, particularly in mitochondria where it could process intermediates of the urea cycle or related pathways.
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

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