protein 504 words KG: PROTEINDRUGTARGETS 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

Protein Drug Targets

🔬 Protein Info
Gene SymbolPROTEINDRUGTARGETS
AliasesPROTEINDRUGTARGETS
TargetProtein
BACE1Beta-secretase
[Gamma-secretase](/entities/gamma-secretase)PSEN1/2 complex
[Amyloid-beta](/proteins/amyloid-beta)Aβ aggregation
Amyloid-betaAβ production
Tau kinasesGSK3β, CDK5
Tau aggregationMAPT
TauTau clearance
AChEAcetylcholinesterase
[NMDA receptor](/entities/nmda-receptor)GRIN1/2
Muscarinic receptorCHRM1, CHRM3
5-HT receptorHTR2A, HTR6
[TREM2](/proteins/trem2)TREM2
CD33CD33
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Adenosine-Astrocyte Metabolic Reset
Score: 0.56
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TREM2-mediated microglial tau clearance enhancement
Score: 0.49

Related Analyses (9)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in