| Gene Symbol | PTPRBPROTEIN |
| Protein Type | Receptor |
| Function | is a critical regulator of vascular development, angiogenesis, and blood-brain barrier (BBB) integrity. |
| Primary Expression | endothelial cells and plays essential roles in embryonic vascular development, maintaining vascular homeostasis, and regulating the neurovascular unit |
| Subcellular Localization | </strong></td><td>Cell membrane, endothelial junctions</td></tr> |
| Molecular Weight | 200 kDa |
| Amino Acids | 2135 aa |
| GeneCards | PTPRBPROTEIN |
| Human Protein Atlas | PTPRBPROTEIN |
| Fibronectin repeats | Mediate protein-protein interactions and adhesion properties |
| MAM domain | Involved in cell-cell recognition and adhesion |
| Phosphatase domain | Catalytically active, dephosphorylates VEGFR2, Tie2, and VE-cadherin |
| Dimerization | PTPRB forms homodimers at endothelial cell junctions |
| N-linked glycosylation | Extensive glycosylation in the extracellular domain affects protein folding and localization |
| Phosphorylation | Tyrosine phosphorylation regulates PTPRB activity and interactions |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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