| Gene Symbol | PUM2PROTEIN |
| Function | is a highly conserved RNA-binding protein that plays critical roles in post-transcriptional gene regulation throughout development and in adult neuronal function. |
| Subcellular Localization | 3' UTRs of target mRNAs[@arrington2016] |
| Molecular Weight | 120 kDa |
| GeneCards | PUM2PROTEIN |
| Human Protein Atlas | PUM2PROTEIN |
| Nuclear Localization Signals (NLS) | PUM2 contains multiple nuclear localization signals that direct its import into the nucleus, where it participates in pre-mRNA processing and nuclear export of target mRNAs. |
| Nuclear Export Signals (NES) | Functional nuclear export signals allow PUM2 to shuttle between the nucleus and cytoplasm, enabling it to regulate translation in the cytoplasmic compartment. |
| Sumoylation | PUM2 can be modified by SUMO (small ubiquitin-like modifier), which affects its subcellular localization and transcriptional regulatory function. |
| Acetylation | Acetylation of lysine residues influences protein stability and interactions with co-factors. |
| Neural Stem Cell Maintenance | PUM2 regulates the balance between neural stem cell self-renewal and differentiation by controlling the translation of key transcription factors and cell cycle regulators. |
| Neuronal Differentiation | As neural stem cells commit to neuronal fates, PUM2 expression patterns shift to regulate the expression of differentiation-associated genes. |
| Axon Guidance and Dendritogenesis | PUM2 regulates the translation of guidance molecules and cytoskeletal proteins necessary for proper neurite outgrowth and dendritic arborization. |
| Long-Term Depression (LTD) | Similarly, PUM2 regulates proteins necessary for LTD, including mechanisms involving AMPA receptor internalization. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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