protein 1,316 words KG: RAPGEF1PROTEIN 2026-03-27
kind:proteinsection:proteinsstate:published
Contents

RAPGEF1 Protein (C3G)

🔬 Protein Info
Gene SymbolRAPGEF1
Full NameRap Guanine Nucleotide Exchange Factor 1
Chromosome9q34.13
Functionis a critical signaling molecule that serves as a guanine nucleotide exchange factor (GEF) for small GTPases Rap1 and R-Ras.
Primary Expressionthe central nervous system, particularly in hippocampal neurons, cortical pyramidal cells, and cerebellar Purkinje cells
Subcellular Localization</strong></td><td>Cytoplasm, Membrane, Synapse</td></tr>
Molecular Weight116 kDa
Amino Acids047 aa
Exons23
UniProt IDQ9Y238
NCBI Gene ID2889
Ensembl IDENSG00000107281
OMIM600996
GeneCardsRAPGEF1
Human Protein AtlasRAPGEF1
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.46
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.46
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.46
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.46
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.46

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in