| Gene Symbol | RIM2 |
| Aliases | RIM2PROTEIN |
| Function | is a critical regulator of synaptic vesicle trafficking and neurotransmitter release in the central nervous system. |
| Subcellular Localization | to presynaptic active zones where it organizes the synaptic vesicle release mach |
| Molecular Weight | 200 kDa |
| Ensembl ID | ENSG00000156413 |
| GeneCards | RIM2 |
| Human Protein Atlas | RIM2 |
| N-terminal zinc finger domain (ZF) | Binds to Rab3-GTP on synaptic vesicles |
| PDZ domain | Interacts with scaffolding proteins and voltage-gated calcium channels |
| SH3 domain | Binds to Munc13 and other proline-rich proteins |
| C2 domain | Calcium/lipid-binding domain involved in membrane interactions |
| RIM2α | Full-length isoform with all domains |
| RIM2β | Shorter isoform lacking the Rab3-binding domain |
| RIM2γ | Brain-specific isoform with unique N-terminus |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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