| Gene Symbol | SCN3A |
| Aliases | Sodium Voltage-Gated Channel Alpha Subunit 3 |
| Chromosome | 12q13 |
| Protein Type | Gene |
| Function | SCN3A encodes Nav1.3, a voltage-gated sodium channel alpha subunit that mediates the inward sodium current (I_Na) essential for action potential generation and propagation. |
| Primary Expression | the central nervous system during development |
| Molecular Weight | 260 kDa |
| GeneCards | SCN3A |
| Human Protein Atlas | SCN3A |
| SCN1A | Sodium channel alpha-1 subunit; major contributor to neuronal excitability |
| SCN2A | Sodium channel alpha-2 subunit; essential for action potential initiation |
| CACNA1A | Calcium channel involved in excitotoxic processes |
| GRIN2B | NMDA receptor subunit; couples to sodium-mediated excitotoxicity |
| FHF Proteins | Regulatory factors modulating SCN3A function |
| Ankyrin-G | Scaffolding protein organizing ion channels at nodes of Ranvier |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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