| Gene Symbol | SLACKCHANNEL |
| Protein Type | Channel |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the brain, particularly in the cortex, hippocampus, thalamus, and basal ganglia, where it regulates neuronal firing patterns and protects against sodi |
| Subcellular Localization | </b></td><td>Plasma membrane, Neuronal membranes, Dendrites</td></tr> |
| Molecular Weight | 110 kDa |
| GeneCards | SLACKCHANNEL |
| Human Protein Atlas | SLACKCHANNEL |
| Transmembrane domains | 6 TM segments (S1-S6) typical of voltage-gated potassium channels |
| Voltage sensor | S4 segment contains positively charged residues for voltage sensing |
| Pore region | Hinged-lid mechanism for K+ selectivity and conductance |
| Cytoplasmic C-terminal tail | Contains the unique sodium-sensing region |
| Slo domain | Characteristic of Slo family channels, involved in ligand sensing |
| Sodium-activated K+ current | Provides outward K+ current activated by intracellular Na+ accumulation during repetitive firing |
| Repolarization assistance | Helps repolarize neurons after action potentials, especially during high-frequency firing |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |