| Gene Symbol | SNX2 |
| Aliases | SNX2PROTEIN |
| Function | SNX2 (Sorting Nexin 2) is a key component of the membrane trafficking machinery with multiple essential cellular functions: |
| Molecular Weight | 47 kDa |
| Ensembl ID | ENSG00000136053 |
| GeneCards | SNX2 |
| Human Protein Atlas | SNX2 |
| PX Domain | Phosphoinositide-binding module |
| Bar Domain | Membrane deformation capability |
| Coiled-coil regions | Protein interactions |
| Endosomal Trafficking Dysfunction | Early AD pathology shows enlarged endosomes; SNX2 knockdown in neuronal cultures increases amyloid-beta secretion |
| Retromer-Mediated Recycling | The SNX2-SNX5-SNX6 heterotrimer recycles APP away from the amyloidogenic pathway |
| LRRK2 Pathogenesis | LRRK2 G2019S mutation causes increased SNX2 phosphorylation, affecting retromer function |
| alpha-Suclein Trafficking | SNX2 regulates trafficking of alpha-synuclein and its interaction with synaptic vesicles |
| GBA-Associated PD | GBA mutations reduce glucocerebrosidase activity, leading to SNX2-dependent lysosomal trafficking defects |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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