| Gene Symbol | SPASTIN |
| Aliases | SPASTINPROTEIN |
| Function | Spastin Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | SPASTIN |
| Human Protein Atlas | SPASTIN |
| Axonal transport | Maintains microtubule tracks |
| Endosomal trafficking | Regulates endosomal morphology |
| Nuclear envelope | Maintains nuclear membrane integrity |
| [Autophagy](/entities/autophagy) | Involved in autophagosome formation |
| Synaptic function | Presynaptic terminal organization |
| Aspect | Details |
| Inheritance | Autosomal dominant |
| Prevalence | ~40% of autosomal dominant HSP |
| Mechanism | Loss of function, haploinsufficiency |
| Onset | Variable, can be childhood to adult |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |