| Gene Symbol | STXBP5 |
| Full Name | Syntaxin Binding Protein 5 |
| Aliases | Lethal Giant Larvae Homolog 2 |
| Chromosome | 6p24.3 |
| Function | is a member of the STXBP (Syntaxin Binding Protein) family. |
| Subcellular Localization | </td><td>Cytoplasm, synaptic vesicles, presynaptic terminals</td></tr> |
| Amino Acids | 593 aa |
| Exons | 20 |
| GeneCards | STXBP5 |
| Human Protein Atlas | STXBP5 |
| Synaptic dysfunction | Altered Tomosyn expression contributes to synaptic vesicle release deficits in Alzheimer's disease models |
| Memory deficits | Mouse models of Alzheimer's disease show increased Tomosyn expression, which correlates with memory impairments [@zhang2019] |
| Dopamine release | Tomosyn regulates dopamine release from striatal terminals |
| Therapeutic potential | Targeting Tomosyn-mediated signaling may improve dopaminergic transmission [@liu2021] |
| Seizure susceptibility | Altered Tomosyn expression and splicing have been observed in epileptic tissue |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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