| Gene Symbol | SV2BPROTEIN |
| Full Name | Synaptic Vesicle Glycoprotein 2B |
| Protein Type | Protein |
| Function | is an integral membrane protein localized to synaptic vesicles that plays essential roles in neurotransmitter release and synaptic function. |
| Primary Expression | the central nervous system, with particular abundance in the hippocampus, cortex, and cerebellum—regions critically affected |
| Subcellular Localization | to synaptic vesicles that plays essential roles in neurotransmitter release and |
| UniProt ID | Search UniProt |
| GeneCards | SV2BPROTEIN |
| Human Protein Atlas | SV2BPROTEIN |
| 12 transmembrane helices | Arranged in the characteristic MFS fold, forming a putative transport channel |
| Large luminal loop | Contains multiple glycosylation sites and the binding site for botulinum neurotoxins |
| Cytoplasmic termini | Short N- and C-terminal domains facing the cytoplasm |
| Conserved regions | Cysteine residues and sequence motifs shared across the SV2 family |
| Release probability | SV2B influences the probability of vesicle fusion |
| Release kinetics | Modulates the timing and dynamics of neurotransmitter release |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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