| Gene Symbol | SYNAPTOTAGMIN3PROTEIN |
| Aliases | SYNAPTOTAGMIN3PROTEIN |
| Chromosome | 19q13.42 |
| Function | of 422 amino acids |
| Hippocampus | CA1 pyramidal neurons and dentate gyrus granule cells |
| Cerebral cortex | Layer 2/3 pyramidal neurons |
| Cerebellum | Purkinje cells and granule cells |
| Thalamus | Specific relay nuclei |
| Two C2 domains | C2A and C2B for Ca²⁺ binding, each comprising approximately 130 amino acids |
| Transmembrane region | A single-pass transmembrane anchor that tethers the protein to synaptic vesicle membranes |
| Linker region | A flexible connection between the C2 domains and transmembrane region |
| N-terminal region | Variable across synaptotagmin isoforms, involved in protein-protein interactions[@syt2017] |
| High affinity | Kd in micromolar range (1-10 μM) |
| Specificity | Selective for Ca²⁺ over other cations like Mg²⁺ |
| Conformational changes | Ca²⁺ binding triggers structural changes that enable interaction with the SNARE complex |
| Rapid kinetics | Association and dissociation rates allow for fast response to calcium influx[@domain2018] |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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