| Gene Symbol | SYNE1 |
| Full Name | Spectrin Repeat Containing Nuclear Envelope Protein 1 |
| Aliases | Page for SYNE1 Gene |
| Chromosome | 6q25.1 |
| Function | SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) encodes nesprin-1, a giant protein involved in nuclear envelope organization and cytoskeletal linkages |
| Subcellular Localization | </b></td><td>Nuclear envelope, outer nuclear membrane, cytoplasmic</td></tr> |
| Molecular Weight | 879 kDa |
| UniProt ID | Q8NF91 |
| NCBI Gene ID | 23345 |
| Ensembl ID | ENSG00000188352 |
| OMIM | 608441 |
| GeneCards | SYNE1 |
| Human Protein Atlas | SYNE1 |
| Multiple spectrin repeats | ~56 triple-helical spectrin repeats form a flexible rod domain |
| KASH domain | A C-terminal transmembrane KASH (Klarsicht/ANC-1/Syne Homology) domain anchors the protein to the outer nuclear membrane |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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