| Gene Symbol | TARDNABINDINGPROTEIN43 |
| Aliases | TARDNABINDINGPROTEIN43 |
| Chromosome | 1p36.22 |
| Function | Mediates both transcriptional repression and RNA splicing regulation |
| Nuclear Localization Signal (NLS) | Residues 82-98, a basic region mediating importin-α/β binding |
| Dimerization domain | Enables TDP-43 to form homodimers and higher-order oligomers |
| Nuclear export signal (NES) | Recently identified in this region |
| Recognition motif | RRM1 has high affinity for UG-rich sequences (TAR DNA, UG repeats) |
| Structure | Classical RRM fold with RNP1 and RNP2 consensus sequences |
| Binding specificity | Single-stranded DNA and RNA, with preference for pyrimidine-rich sequences |
| Auxiliary RNA binding | Enhances specificity and affinity for target RNAs |
| Splicing regulation | Critical for exon skipping events (e.g., CFTR exon 9, SMN2 exon 7) |
| Structural role | Stabilizes RRM1 binding through inter-domain interactions |
| HnRNP interactions | Binds to other hnRNP proteins (A1, A2/B1, C) |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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