| Gene Symbol | TGM6PROTEIN |
| Function | is a protein encoded by the TGM6 gene. |
| Subcellular Localization | ** | Cytoplasm, cell surface, extracellular | |
| Molecular Weight | 79 kDa |
| GeneCards | TGM6PROTEIN |
| Human Protein Atlas | TGM6PROTEIN |
| Calcium (Ca²⁺) | Binding of calcium ions (multiple sites) induces a conformational change from the compact/closed (inactive) to the extended/open (active) form, exposing the catalytic site |
| GTP/GDP | Binding of GTP/GDP stabilizes the compact inactive conformation, opposing calcium activation (allosteric regulation) |
| Reducing conditions | The active-site cysteine must be in the reduced (thiol) form |
| Closed/compact form | GTP/GDP-bound; catalytically inactive; β-barrel domains packed against the catalytic core, blocking substrate access |
| Open/extended form | Ca²⁺-bound; catalytically active; β-barrels swing away from the core, exposing the active site and substrate-binding groove |
| Cytoskeletal proteins | Tubulin, actin, neurofilaments; cross-linking stabilizes the neuronal cytoskeleton |
| Myelin basic protein (MBP) | Cross-linking by TG6 in oligodendrocytes may stabilize myelin sheaths |
| [Tau](/proteins/tau) | Tau protein is a substrate for transglutaminase-mediated cross-linking; cross-linked tau is resistant to proteolytic degradation and may contribute to tangle formation |
| Alpha-synuclein | α-Synuclein cross-linking promotes oligomerization and may accelerate Lewy body pathology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |