protein 926 words KG: TPPPPROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

TPPP/p25alpha Protein

🔬 Protein Info
Gene SymbolTPPPPROTEIN
Functionis a 219 amino acid intrinsically disordered protein that stabilizes microtubules and promotes tubulin acetylation in oligodendrocytes.
Subcellular Localization</td><td>Cytoplasm (perinuclear, cell processes in oligodendrocytes)</td></tr>
Molecular Weight24 kDa
GeneCardsTPPPPROTEIN
Human Protein AtlasTPPPPROTEIN
GTPase active siteThe Walker A motif (GxxxxGK) and Walker B motif (DxxG) enable GTP hydrolysis with Km ~ 30 μM, similar to small GTPases
TPPP2Testis-specific
TPPP3/p20Broader tissue expression, ciliary function
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph