| Gene Symbol | TUBB4A |
| Full Name | Tubulin Beta 4A Class IVa |
| Aliases | TUBB4APROTEIN |
| Chromosome | 19p13 |
| Function | TUBB4A encodes tubulin beta 4A, a major constituent of microtubules, the cytoskeletal filaments essential for cell structure, intracellular transport, and cell division. |
| UniProt ID | [P04350](https://www.uniprot.org/uniprot/P04350) |
| Ensembl ID | ENSG00000176014 |
| OMIM | 602917 |
| GeneCards | TUBB4A |
| Human Protein Atlas | TUBB4A |
| Alpha-tubulin | Obligate heterodimeric partner in microtubule assembly |
| Microtubule-associated proteins (MAPs) | Regulators of microtubule dynamics interacting with TUBB4A |
| Hypomyelinating leukodystrophies | Primary clinical manifestations of TUBB4A mutations |
| Other beta-tubulin isoforms | TUBB, TUBB2A, TUBB2B with distinct tissue expression and disease associations |
| Axonal transport machinery | Kinesin and dynein motors dependent on TUBB4A-containing microtubules |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |