| Gene Symbol | VESICULARMONOAMINETRANSPORTER1 |
| Aliases | VESICULARMONOAMINETRANSPORTER1 |
| Chromosome | 8p21.3 |
| Function | VMAT1 transports monoamine neurotransmitters from the cytoplasm into synaptic vesicles: [@lohr2020] |
| Gene | SLC18A1 (chromosome 8p21.3) |
| Protein Class | Vesicular monoamine transporter (VMAT) |
| Protein Size | 525 amino acids |
| Primary Localization | Synaptic vesicle membrane of monoaminergic neurons |
| Substrates | Dopamine, norepinephrine, epinephrine, serotonin, histamine |
| Disease Associations | Depression, bipolar disorder, neurodegenerative diseases |
| Therapeutic Relevance | Target for VMAT inhibitors, drug delivery |
| 12 transmembrane domains | Form the transporter pore |
| Vesicular H+-ATPase binding site | Uses proton gradient for transport |
| Monoamine binding pocket | Recognizes various monoamine substrates |
| Cytoplasmic loops | Contain regulatory domains |
| Vesicular H+-ATPase | Generates the proton gradient |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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