| Gene Symbol | VPS53 |
| Aliases | VPS53PROTEIN |
| Chromosome | 17p13.1 |
| Function | VPS53 (Vacuolar Protein Sorting 53 Homolog) is a component of the HOPS (Homotypic fusion and Vacuolar Protein Sorting) complex, which plays a critical role in lysosomal trafficking and autophagy. |
| Primary Expression | neurons and glial cells, with high expression in the cerebral cortex, [hippocampus](/brain-regions/hippo |
| Subcellular Localization | </strong></td><td>Endosomes, Lysosomes, Golgi apparatus</td></tr> |
| Molecular Weight | 79 kDa |
| Amino Acids | 672 aa |
| Ensembl ID | ENSG00000156502 |
| GeneCards | VPS53 |
| Human Protein Atlas | VPS53 |
| N-terminal domain (aa 1-200) | Interactions with other HOPS/CORVET subunits, particularly VPS16 and VPS33. This region contains binding sites for the core complex assembly. |
| Central region (aa 200-450) | Scaffold for complex formation, providing the structural framework for the hexameric HOPS complex. This region contains alpha-helical domains that mediate subunit-subunit interactions. |
| C-terminal region (aa 450-672) | Conserved WD40-like beta-propeller repeats that may function in protein-protein interactions and membrane recognition. This domain is important for cargo recognition and recruitment. |
| Phosphorylation | VPS53 can be phosphorylated at multiple serine/threonine residues, potentially regulating complex assembly and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |