| Gene Symbol | WDR7 |
| Chromosome | 18q21.1 |
| Function | Mitochondrial morphology control: WDR7 regulates mitochondrial dynamics by influencing fusion and fission processes. |
| Subcellular Localization | </th><td>Mitochondria (inner mitochondrial membrane)</td></tr> [@tau2020] |
| Molecular Weight | 68 kDa |
| Amino Acids | 642 aa |
| Exons | 21 |
| Pathways | TGF-β |
| GeneCards | WDR7 |
| Human Protein Atlas | WDR7 |
| N-terminal transmembrane regions | Multiple hydrophobic alpha-helical transmembrane segments that anchor the protein to the inner mitochondrial membrane |
| TMBIM domain | The characteristic BAX inhibitor motif at the C-terminus, consisting of six transmembrane helices forming a pore-like structure |
| WD repeat regions | Multiple WD40 repeat domains involved in protein-protein interactions |
| Metabolic adaptation | WDR7 expression responds to cellular metabolic states, linking mitochondrial function to nutrient availability and energy demands [6]. |
| ROS regulation | By maintaining mitochondrial integrity, WDR7 helps control reactive oxygen species (ROS) production and oxidative stress management. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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