disease 1,089 words KG: ent-dise-520a56c3
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Cognitive Impairment in Progressive Supranuclear Palsy

Disease Info
Reduced verbal fluencyBoth phonemic and category fluency are impaired, with early deficits in letter-based word generation[@rascovsky2001]
Impaired set-shiftingDifficulties with the Wisconsin Card Sorting Test reflect disrupted task-switching abilities[@grafman1995]
Planning and organizationReduced performance on tasks requiring sequential planning, such as the Tower of London test[@phuong2019]
Working memory deficitsImpaired maintenance and manipulation of information in working memory[@dubois2000]
Reduced attention spanDifficulty maintaining sustained attention on tasks[@cotter2018]
Selective attentionImpaired ability to filter irrelevant stimuli
Divided attentionSignificant problems with multitasking
Retrieval deficitsDifficulty recalling information without substantial cues
Working memoryImpaired temporary storage and manipulation
Preserved recognitionRecognition memory relatively intact compared to free recall
DisinhibitionSome patients demonstrate inappropriate social behavior
IrritabilityMood lability and increased irritability
DatabasesOMIMOrphanetClinicalTrialsPubMed

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