| Estimated prevalence | 5-7 per 100,000 population[@psp2023] |
| Range by region | 3-10 per 100,000 depending on study methodology |
| Estimated US population | Approximately 20,000-30,000 individuals |
| Annual incidence | 0.5-1.0 per 100,000 person-years |
| Age-adjusted incidence | Increases sharply after age 50 |
| Peak incidence | 60-70 years |
| Mean age of onset | 63-68 years |
| Median age | 66 years |
| Range | 40-85 years |
| Early-onset PSP | <50 years (rare, <5% of cases) |
| Slight male predominance | 1.2-1.5:1 ratio |
| [MAPT](/proteins/tau) H1 haplotype | Strongest genetic risk factor[@mapt2022] |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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