| Delayed-onset PTSD | Symptoms emerge at least 6 months after trauma exposure |
| Complex PTSD | Resulting from prolonged, repeated trauma (e.g., childhood abuse) |
| Subsyndromal PTSD | Significant symptoms not meeting full diagnostic criteria |
| Enhanced Acquisition | Stronger conditioned fear responses to neutral stimuli paired with threat |
| Impaired Extinction | Reduced ability to learn safety signals |
| Extinction Recall Deficits | Failure to recall previously learned safety |
| Generalization | Extinction of fear responses to novel contexts |
| Enhanced Negative Feedback | Paradoxically, PTSD is associated with enhanced glucocorticoid negative feedback, despite elevated baseline cortisol in some studies[^8] |
| Reduced Cortisol Levels | Some studies find lower baseline cortisol in PTSD, potentially reflecting prior hyperactivation and exhaustion[^8] |
| Databases | OMIMOrphanetClinicalTrialsPubMed |